Can Zofran be given intranasal?
These results suggest that intranasal administration of ondansetron can be an effective substitute for intravenous administration for the prevention of cisplatin-induced acute emesis.
Why was Zofran taken off the market?
WASHINGTON — The 32-mg dose of the anti-nausea drug ondansetron (Zofran) has been pulled from the market because of concerns about cardiac problems, the FDA announced Tuesday. Ondansetron is approved for preventing chemotherapy-induced nausea and vomiting, and, in lower doses, for postoperative nausea and vomiting.
What Zofran used for?
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body’s natural substances (serotonin) that causes vomiting.
How does Zomig Nasal Spray work?
It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Zolmitriptan does not prevent migraine attacks or reduce the number of headaches you have.
Who Cannot take Zofran?
You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Is Zofran being taken off the market?
The 32-mg, single intravenous dose of Zofran (ondansetron), an anti-nausea drug, is being removed from the market due to its potential to cause serious, even fatal, cardiac damage, according to a Drug Safety Communication issued Dec. 4 by the U.S. Food and Drug Administration.
When should you not take Zofran?
low amount of potassium in the blood. extrapyramidal disease, a type of movement disorder. neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion. serotonin syndrome, a type of disorder with high serotonin levels.
How fast does Zofran work?
How quickly does Zofran (ondansetron) work? Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.
Is there anything stronger than Zofran for nausea?
Reglan (metoclopramide) is a dopamine antagonist that is used as an antiemetic (anti-vomiting) agent used to treat nausea, vomiting, loss of appetite, heartburn and early satiety (feeling of fullness). Reglan is available in generic form.
Does nasal spray help migraines?
Nasal sprays can provide relief to migraine patients in as soon as 15 minutes, and are especially useful with nausea and vomiting, or in those who seek to avoid an injection. They are sprayed into the nostril with the head upright.
Can you take Zofran if allergic to ondansetron?
You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Why do you take Zofran for nausea and vomiting?
Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Zofran may be used for purposes not listed in this medication guide.
What are the side effects of Zofran in cancer?
ZOFRAN is a 5-HT3 receptor antagonist indicated for the prevention of: nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m2. (1) nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. (1)
How much phenylalanine is in Zofran ODT tablets?
Phenylketonuric patients should be informed that ZOFRAN ODT orally disintegrating tablets contain phenylalanine (a component of aspartame). Each 4-mg and 8-mg orally disintegrating tablet contains less than 0.03 mg phenylalanine. (5.5) —————————— ADVERSE REACTIONS —————————–