Is DNA a ligase?

DNA ligase is a specific type of enzyme, a ligase, (EC 6.5. 1.1) that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond….DNA ligase.

ligase I, DNA, ATP-dependent
Symbol LIG1
NCBI gene 3978
HGNC 6598
OMIM 126391

Is carboxylase a ligase?

The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming)….Biotin—(acetyl-CoA-carboxylase) ligase.

biotin-[acetyl-CoA-carboxylase] ligase
ExPASy NiceZyme view
MetaCyc metabolic pathway

What is the function of SMURF1 E3 ubiquitin ligase 1?

SMURF1 SMAD specific E3 ubiquitin protein ligase 1 [ (human)] Summary. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity.

What is the EC number of PIAS1 protein ligase?

E3 SUMO-protein ligase PIAS1 (EC: 2.3.2.- Search proteins in UniProtKB for this EC number. See the description of this EC number in ENZYME. Search reactions for this EC number in Rhea.

Why is SMURF1 important for S phase progression?

Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1; these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 = wee 1 homolog [S pombe] protein)

What is the role of E3 E3 ligase?

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.