Is DNA a ligase?
DNA ligase is a specific type of enzyme, a ligase, (EC 6.5. 1.1) that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond….DNA ligase.
| ligase I, DNA, ATP-dependent | |
|---|---|
| Symbol | LIG1 |
| NCBI gene | 3978 |
| HGNC | 6598 |
| OMIM | 126391 |
Is carboxylase a ligase?
The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming)….Biotin—(acetyl-CoA-carboxylase) ligase.
| biotin-[acetyl-CoA-carboxylase] ligase | |
|---|---|
| Identifiers | |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
What is the function of SMURF1 E3 ubiquitin ligase 1?
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 [ (human)] Summary. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity.
What is the EC number of PIAS1 protein ligase?
E3 SUMO-protein ligase PIAS1 (EC: 2.3.2.- Search proteins in UniProtKB for this EC number. See the description of this EC number in ENZYME. Search reactions for this EC number in Rhea.
Why is SMURF1 important for S phase progression?
Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1; these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 = wee 1 homolog [S pombe] protein)
What is the role of E3 E3 ligase?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.