Is propylthiouracil safe during breastfeeding?

No adverse effects have been reported in babies whose mothers used PTU while breastfeeding. Studies show that PTU does not significantly affect the breastfed infants’ thyroid function. If you are worried about any symptoms that the baby has, contact the child’s healthcare provider.

Is propylthiouracil safe during pregnancy?

Both methimazole (MMI) and propylthiouracil (PTU) may be used during pregnancy; however, PTU is preferred in the first trimester and should be replaced by MMI after this trimester.

Can I breastfeed if I have hyperthyroidism?

High thyroid levels (hyperthyroid) Hyperthyroidism is not a contraindication for breastfeeding. Per Medications and Mothers’ Milk (Hale 2017, p. 558-559, 564-565), only exceedingly low levels of thyroid hormones (both T4/levothyroxine and T3/liothyronine) transfer into breastmilk.

How long does it take for propylthiouracil to start working?

Propylthiouracil should have some effect on your symptoms around three to four weeks after treatment starts. Your thyroid hormone levels should be stabilised within four to eight weeks. Continue to take the tablets for as long as you are advised to do so by your doctor.

What are the side effects of propylthiouracil?

Propylthiouracil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • hair loss.
  • difficulty tasting food.
  • numbness, burning, or tingling of the hands or feet.
  • joint or muscle pain.
  • dizziness.
  • swelling of the neck.

Why is propylthiouracil given during pregnancy?

Propylthiouracil is the drug of choice for hyperthyroidism during pregnancy in North America owing to the suspected association of methimazole with congenital abnormalities (sometimes referred to as methimazole embryopathy), characterized by aplasia cutis, esophageal atresia, choanal atresia, facial abnormalities, and …

How quickly does propylthiouracil work?

How long will drugs stay in breastmilk?

Drugs. If you use amphetamines, ecstasy, cocaine or heroin, you should not breastfeed for 24 hours after use. If you smoke cannabis or tobacco you should breastfeed your baby before you smoke, and smoke outside and away from the baby.

Does thyroid affect lactation?

Thyroid hormones play a role in normal breast development and helping breasts to make milk. When not enough of the thyroid hormones are made, a mother’s milk supply may be affected. Hypothyroidism is treated with thyroxine in order to bring the levels back to normal.

Can breastfeeding affect TSH levels?

Lactating women showed more pronounced decrease of thyroxine, decreased thyroxine: triiodothyronine ratio and increased TSH level during the 10th week after parturition in comparison to IL group. The women on NL group showed similar changes as L women, but without increased level of TSH in comparison to IL ones.

Is it safe to take propylthiouracil during lactation?

Summary of Use during Lactation. Propylthiouracil (PTU) had been considered the antithyroid drug of choice during lactation;[1][2] however, findings that the rates of liver injury higher with PTU than with methimazole has altered this judgement.[3] Some experts now recommend that methimazole should be considered the antithyroid drug…

How does propylthiouracil ( PTU ) affect milk production?

Studies show that PTU does not significantly affect the breastfed infants’ thyroid function. If you are worried about any symptoms that the baby has, contact the child’s healthcare provider. PTU has not been shown to affect milk production. Untreated hyperthyroidism and hypothyroidism may affect milk production.

How much propylthiouracil can a woman take in 24 hours?

Maternal Levels. A woman (time postpartum not stated) given a single dose of 100 mg of propylthiouracil (PTU) excreted a total of 0.077% of the dose in her breastmilk in 24 hours. [7]

When is the best time to take propylthiouracil?

After a single oral dose of 400 mg of propylthiouracil (PTU) in 9 women who were 1 to 9 months postpartum, peak milk levels averaging 0.7 mg/L were reached 1.5 hours after the dose.