What are the signs and symptoms of acute tubular necrosis?

Symptoms of acute tubular necrosis include:

  • A small amount of urine output.
  • Swelling and fluid retention.
  • Nausea and vomiting.
  • Trouble waking up/drowsiness.
  • Feeling sluggish.
  • Confusion.

What are the 3 phases of ATN?

The course of ATN can be divided into three phases:

  • Onset or initiating phase. Lasting hours or days, this is the time from onset of the precipitating event (for example, toxin exposure) until tubular injury occurs.
  • Maintenance phase.
  • Recovery phase.

How long does ATN last?

ATN can last for a few days to 6 weeks or more. This may be followed by 1 or 2 days of making an unusually large amount of urine as the kidneys recover. Kidney function often returns to normal, but there may be other serious problems and complications.

What are the 2 types of ATN?


  • ischemic ATN occurs when severe hypotension leads to decreased renal perfusion.
  • toxic ATN occurs when a nephrotoxic drug decreases renal perfusion and/or causes tubular injury.

What are the long term effects of acute tubular necrosis?

ATN has also been associated with negative long term outcomes including progression to chronic kidney disease, end-stage renal disease, and long term mortality. Mortality associated with ATN is 37% in hospitalized patients and 78% in intensive care unit (ICU) patients.

How is acute tubular necrosis treated?

Intravenous furosemide or bumetanide in a single high dose (ie, 100-200 mg of furosemide) is commonly used, although little evidence indicates that it changes the course of ATN. The drug should be infused slowly because high doses can lead to hearing loss. If no response occurs, the treatment should be discontinued.

How is ATN treated?

Does acute tubular necrosis cause pain?

People with acute tubular necrosis usually have no symptoms. However, if the condition is severe, kidney failure. Kidney failure has many possible causes.

Are there long term effects of acute tubular necrosis?

Long-term outcome after ARF depends on absence of co-morbid factors, cause of initial admission and age. Although the late mortality rate is high and related with the original disease, renal function is adequate in most patients.