What does Epileptogenesis mean?

Epileptogenesis is the development and extension of tissue capable of generating spontaneous seizures, resulting in a) development of an epileptic condition and/or b) progression of the epilepsy after it is established [35].

What is an Epileptogenic lesion?

Epileptogenic lesions include posttraumatic gliosis, focal cortical dysplasias, and heterotopias, vascular malformations such as cavernous hemangiomas, low-grade tumors such as dysembryoplastic neuroepithelial tumors, gangliogliomas, pleomorphic xanthoastrocytomas, oligodendrogliomas, and astrocytomas.

What causes TLE?

Causes. The causes of TLE include mesial temporal sclerosis, traumatic brain injury, brain infections, such as encephalitis and meningitis, hypoxic brain injury, stroke, cerebral tumours, and genetic syndromes. Temporal lobe epilepsy is not the result of psychiatric illness or fragility of the personality.

What is a seizure?

A seizure is a burst of uncontrolled electrical activity between brain cells (also called neurons or nerve cells) that causes temporary abnormalities in muscle tone or movements (stiffness, twitching or limpness), behaviors, sensations or states of awareness. Seizures are not all alike.

What causes Epileptogenesis?

Epileptogenesis is defined as the process during which changes occur in the brain after a precipitating injury or insult that results in the development of spontaneous recurrent seizure activity or epilepsy.

What’s focal epilepsy?

Focal epilepsy is a neurological condition in which the predominant symptom is recurring seizures that affect one hemisphere (half) of the brain.

Can TLE go away?

What is the outlook? Two out of 3 people with temporal lobe epilepsy achieve good seizure control with seizure medication. Seizures may also go away in some children with TLE. A good outcome is most often seen in people with normal MRI scans.

What do we know about the neurobiology of epilepsy?

It refers to the sequence of events that converts the normal brain into one that can support a seizure. It is assumed that groups of neurons become hyperexcitable, poised to abnormally discharge. Much of what we know about epilepsy emerged in the 1800s with the first evaluation of autopsy specimens from individuals with epilepsy.

Is there a single mechanism that causes epilepsy?

Epilepsy is a complex disease with diverse clinical characteristics that preclude a singular mechanism. One way to gain insight into potential mechanisms is to reduce the features of epilepsy to its basic components: seizures, epileptogenesis, and the state of recurrent unprovoked seizures that defines epilepsy itself.

Why are seizures more difficult to diagnose with epilepsy?

In contrast, understanding seizures in the brain of an individual with epilepsy is more difficult because seizures are typically superimposed on an altered nervous system. The different environment includes diverse changes, making mechanistic predictions a challenge.

Are there control points for temporal lobe epilepsy?

However, the critical control points for the emergence of chronic seizures in temporal lobe epilepsy, as well as their persistence, frequency, and severity, are questions that remain unresolved. Introduction Seizures and epilepsy have been documented since the earliest civilizations, before much was understood about the nervous system at all.