What does MMP 13 do?

Matrix metalloproteinase (MMP) 13 is a major enzyme that targets cartilage for degradation. It not only targets type II collagen in cartilage for degradation, but also degrades proteoglycan, types IV and type IX collagen, osteonectin and perlecan in cartilage [4].

What is an MMP 13 inhibitor?

Matrix metalloproteinase-13 (MMP-13), an important member of matrix metalloproteinases (MMPs) family, plays a vital role by degrading type II collagen in articular cartilage and bone in OA. Thus, developing selective MMP-13 inhibitors is a potential strategy for the therapy of OA.

What is mmp3 enzyme?

MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 was found to be capable of activating the precursor of IL1-beta.

Which MMP is collagenase?

The 72-kDa gelatinase/type IV collagenase (MMP-2) is a member of the matrix metalloproteinase (MMP) family of enzymes. This enzyme is known to cleave type IV collagen as well as degrade denatured collagens.

Does MMP-13 cause neuropathy?

Rieger has determined that, in the presence of paclitaxel, a widely used chemotherapeutic agent, peripheral neuropathy is caused by the increased expression of MMP-13 (matrix-metalloproteinase 13).

Where does MMP-13 come from?

It was originally cloned from human breast cancer tissue [8]. It is produced and secreted from many cell types as a 60-kDa precursor form (proMMP-13), which can be activated to a 48-kDa form via a 50-kDa intermediate by plasmin, MMP-2, MMP-3 and MMP-14 [9], [10].

Does MMP-13 help neuropathy?

The involvement of MMP-13 in both neuropathies and its conservation in mice indicates that the mechanism may be conserved among sensory neuropathies and translate into humans. Therefore, selective MMP-13 inhibitor applications to the epidermis may be a valuable treatment option for diabetic neuropathy.

What does MMP-9 do?

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling.

What is the function of collagenase?

Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium.

What MMP stand for?

Definition. MMP. Mitochondrial Membrane Potential. MMP. Mixed Member Proportional (New Zealand electoral system)

How many MMP are there?

In vertebrates, there are 28 different types of MMPs [1,2,8,9,11,12,13,16,17], at least 23 are expressed in human tissue [1]. MMPs can be subdivided according to bioinformatic analysis, in 5 types [23]: Non-furin regulated MMPs (MMP-1, -3, -7, -8, -10, -12, -13, -20, and -27);

How can I reverse neuropathy naturally?

How To Reverse Peripheral Neuropathy Naturally

  1. Exercise. A number of health conditions; exercise is a remedy.
  2. Quit smoking. Smoking is a causative factor to almost every health condition as smoking affects blood circulation.
  3. Vitamins.
  4. Essential Oils.
  5. Dietary supplementation.
  6. Healthy diet.

Which is the best Antibody to detect MMP-13?

Anti-MMP-13 Antibody (C-3) is a mouse monoclonal IgG 1 κ MMP-13 antibody, cited in 17 publications, provided at 200 µg/ml raised against amino acids 242-471 mapping at the C-terminus of MMP-13 of human origin MMP-13 Antibody (C-3) is recommended for detection of MMP-13 of human origin by WB, IP, IF and ELISA

What kind of cancer is caused by MMP13?

Seems to be specific to breast carcinomas. Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111].

Where does ab39012 recognize the proenzyme of MMP13?

Find out more. ab39012 recognizes the latent proenzyme, at 60 Kd, as well as the active form at 48 Kd, and intermediate activation forms. It does not cross react with the other MMP family members. ab39012 recognizes the Hinge region of MMP13.

Is there a synthetic peptide corresponding to human MMP13?

Synthetic peptide corresponding to Human MMP13 (Hinge). The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.