What does non-nucleoside reverse transcriptase inhibitors do?
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
How do NRTIs and NNRTIs work?
NNRTIs work by binding to the HIV enzyme called reverse transcriptase, which is essential to the viral replication process, and therefore blocking HIV from making copies of itself. Dapivirine is an example of an NNRTI. NRTIs work by mimicking nucleotides that are the building blocks of viral DNA.
What are the Nnrti drugs?
What are NNRTIs? Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are antiviral agents that bind non-competitively to HIV-1’s reverse transcriptase and prevents viral RNA conversion to DNA. They are used to treat human immunodeficiency virus (HIV infection) and acquired immune deficiency syndrome (AIDS).
How does nucleoside reverse transcriptase inhibitors work?
Nucleoside Reverse Transcriptase Inhibitors (nucleoside analogues, NRTIs or nukes) When the HIV virus enters a healthy cell, it attempts to make copies of itself. It does this by using an enzyme called reverse transcriptase. The NRTIs work because they block that enzyme.
What is the difference between nucleoside and non-nucleoside?
The nucleoside transcriptase inhibitors (NRTIs), have a nucleoside that is structurally similar to the T-cell DNA’s nucleoside. The non-nucleoside transcriptase inhibitors do not get into the cell nucleus or interfere with the DNA. NNRTIs bind directly to the HIV’s reverse transcriptase enzyme and inhibit its activity.
What is the result of a nucleoside analog?
The nucleoside analogues resemble naturally occurring nucleosides and act by causing termination of the nascent DNA chain. They are believed to inhibit viral replication by several mechanisms, either by competitive inhibition of the viral polymerase or by DNA chain termination.
How does the reverse transcriptase work?
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Collectively, these activities enable the enzyme to convert single-stranded RNA into double-stranded cDNA.
What are the results of a review of systems?
A 14-point review of systems is otherwise negative. CONSTITUTIONAL: No fever. No chills. No dizziness. No weakness. EYES: No pain, erythema, or discharge.
Which is better, a NNRTIs or a NRTIs?
On the other hand, since NNRTIs are specific to the viral RT and not expected to interact with host polymerases such as NRTIs might, they have somewhat less potential for side effects than NRTIs.
How are reverse transcriptase inhibitors ( NRTIs ) used in medicine?
Nucleoside Reverse Transcriptase Inhibitors (NRTIs or nukes) The NRTIs work because they block that enzyme. Without reverse transcriptase, HIV can’t make new virus copies of itself. The following drugs are NRTIs that are in current use; their generic names are listed along with their common names, if they have one, and their brand names.
Can a NRTIs be a decoy for a viral RT?
The short answer is yes, they might, but cellular DNA polymerases (working from a DNA template) and viral RTs (working from an RNA template) have enough differences in their enzyme active sites to make it possible to develop NRTIs which don’t bind well to host DNA polymerases but are pretty effective decoys for viral RTs.