What is bortezomib FDA approved for?
The Food and Drug Administration has approved Velcade to treat a type of cancer called multiple myeloma.
When was bortezomib approved by the FDA?
Development Timeline for Velcade
| Date | Article |
|---|---|
| Oct 15, 2007 | Approval FDA Expands Velcade (Bortezomib) for Injection Label for Patients with Multiple Myeloma |
| May 13, 2003 | Approval FDA Approves Velcade (bortezomib) for Injection for the Treatment of Relapsed and Refractory Multiple Myeloma |
What is bortezomib used for?
Bortezomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow). Bortezomib is also used to treat people with mantle cell lymphoma (a fast-growing cancer that begins in the cells of the immune system). Bortezomib is in a class of medications called antineoplastic agents.
Is bortezomib a biologic?
Some intracellular peptides have been shown to be biologically active, and so the effect of bortezomib on the levels of intracellular peptides may contribute to the biological and/or side effects of the drug.
Is bortezomib approved by the FDA?
Bortezomib (formerly PS-341), a promising new drug for the treatment of multiple myeloma, recently received accelerated approval from the U.S. Food and Drug Administration (FDA) for the therapy of patients with progressive myeloma after previous treatment.
What is the mechanism of action of bortezomib?
Mechanism of Action Bortezomib is a selective inhibitor of the 26S proteasome, preventing the activation of NF-κB. It induces apoptosis of rapidly dividing, metabolically active cells with extensive protein synthesis.
Is bortezomib cytotoxic?
Bortezomib is a selective and reversible inhibitor of the 26S proteasome, and mechanistic studies have revealed that inhibition of the proteasome complex leads to accumulation of lysine (K)–48 ubiquitin-linked proteins and consequently to cytotoxic effects in malignant cells.
Can you live a normal life with myeloma?
Multiple myeloma is a type of cancer that affects the bone marrow. Multiple myeloma is a cancer of bone marrow. Bone marrow is the spongy tissue inside the long bones….How long can a person live with multiple myeloma?
| Revised international staging system | Median survival |
|---|---|
| Stage I | 62 months (5 years, 2 months) |
Is bortezomib a chemotherapy?
Drugs used in chemotherapy, such as carfilzomib, lenalidomide, and bortezomib, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
How long is bortezomib in system?
Bortezomib is rapidly distributed into tissues after administration of a single dose, with an initial plasma distribution half-life of less than 10 minutes, followed by a terminal elimination half-life of more than 40 hours.
What is the mechanism of action of thalidomide?
First established as agents with antiangiogenic properties, thalidomide and IMiDs inhibit the production of interleukin (IL)-6, which is a growth factor for the proliferation of myeloma cells. In addition, they activate apoptotic pathways through caspase 8-mediated cell death.