What is cefazolin diluted in?

Dilute the reconstituted 500 mg, 1 g or 2g of Cefazolin-AFT in a minimum of 10 mL of Sterile Water for Injection. Inject solution slowly over a period of 3 to 5 minutes. Do not inject in less than 3 minutes.

How do you give cefazolin?

Cefazolin injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously (into a vein) over a period of 30 minutes. Cefazolin injection can also be given intramuscularly (into a muscle). It is usually given every 6, 8, or 12 hours.

Can cefazolin be reconstituted with normal saline?

The 500 mg vial can be reconstituted with 0.9% Sodium Chloride Injection, Sterile Water for Injection or Bacteriostatic Water for Injection. The 1 g and 2 g vial should only be reconstituted with Sterile Water for Injection or Bacteriostatic Water for Injection.

What happens if you give cefazolin too fast?

Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: dark urine, easy bruising/bleeding, fast/pounding/irregular heartbeat, seizures, unusual weakness, yellowing eyes/skin, mental/mood changes (such as confusion).

Can you IV push cefazolin?

Cefazolin, cefotaxime, cefotetan, cefoxitin, ceftazidime, and cefuroxime are FDA-approved for IV push administration.

What is the concentration of cefazolin?

Single-Dose Vials

Vial Size Amount of Diluent Approximate Concentration
1 g 2.5 mL 330 mg/mL

What antibiotics can be given IV push?

Several antibiotics are Food and Drug Administration–approved for IV push administration, including many beta-lactams. In addition, cefepime, ceftriaxone, ertapenem, gentamicin, and tobramycin have primary literature data to support IV push administration.

What bacteria does cefazolin cover?

Cefazolin is used in a variety of infections provided that susceptible organisms are involved….Spectrum of activity

  • Staphylococcus aureus (including beta-lactamase producing strains)
  • Staphylococcus epidermidis.
  • Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae and other strains of streptococci.

What’s the maximum dose of cefazolin you can take?

Children and Adolescents. A maximum dose of 12 g/day has been used rarely in severe, life-threatening infections. Guidelines recommend cefazolin as an alternate therapy for highly penicillin-susceptible streptococcal infections; treat for 4 weeks for native valve endocarditis (NVE) and for 6 weeks or prosthetic valve endocarditis (PVE).

When does cefazolin reach its peak concentration in urine?

In the first 6 hours approximately 60% of the drug is excreted in the urine and this increases to 70% to 80% within 24 hours. Cefazolin achieves peak urine concentrations of approximately 2,400 mcg/mL and 4,000 mcg/mL respectively following 500 mg and 1 gram intramuscular doses.

What is the maximum concentration of cephalosporin?

One hour after the intramuscular injection of 500 mg of cefazolin, the maximum concentration of 33.3 mug/ml is reached in the serum. The sufficient high levels are sustained for 8 hours.

How often should you take cefazolin for a joint infection?

Usual Adult Dose for Joint Infection Mild infections due to susceptible gram-positive cocci: 250 to 500 mg IV or IM every 8 hours Moderate to severe infections: 500 mg to 1 g IV or IM every 6 to 8 hours Severe, life-threatening infections (e.g., endocarditis, septicemia): 1 to 1.5 g IV every 6 hours