What is metastatic endometrial cancer?
Metastatic uterine (endometrial) cancer is a type of cancer that originated in the lining of the uterus (endometrium) and has spread to distant areas of the body. In general, uterine cancer can metastasize to the rectum or bladder. Other areas where it may spread include the vagina, ovaries and fallopian tubes.
Is metastatic endometrial cancer curable?
While endometrial cancer is a highly curable malignancy when it presents as a uterine-confined disease, the prognosis for recurrent or metastatic disease is poor. The median survival of women enrolled in trials for recurrent or metastatic endometrial cancer hardly exceeds 12 months [7].
What is the survival rate of metastatic uterine cancer?
If the cancer has spread regionally, the 5-year survival rate is 69%. If the uterine cancer is diagnosed after the cancer has spread into other areas of the body, the survival rate is 17%.
What are the patterns of spread of endometrial carcinoma?
The three common spread patterns of endometrial cancer are local invasion, lymphatic spread and hematogenous spread. Vaginal metastasis occurs by submucosal lymphatic or vascular metastases in ~10% of patients with clinical stage I disease. Vaginal implantation metastasis of endometrial cancer is extremely rare.
How long can you live with stage 4 endometrial cancer?
The average duration of response was over 10 months and the average survival was over 16 months. This regimen was administered on an outpatient basis and was well tolerated. These doctors concluded that this was an active treatment regimen for women with advanced or recurrent uterine cancer.
How can you tell if endometrial cancer has returned?
Most endometrial cancer recurrences are found because of symptoms, so it’s very important that you tell your doctor exactly how you’re feeling. If symptoms or the physical exam suggests the cancer might have come back, imaging tests (such as CT scans or ultrasounds), a CA 125 blood test, and/or biopsies may be done.
What is the most aggressive uterine cancer?
Uterine sarcomas, which develop in the muscle tissue of the uterus (the myometrium). This type is rare, but is also the most aggressive form of uterine cancer.
What is the most common type of endometrial carcinoma?
Most endometrial cancers are adenocarcinomas, and endometrioid cancer is the most common type of adenocarcinoma, by far. Endometrioid cancers start in gland cells and look a lot like the normal uterine lining (endometrium).
Which condition is associated with the development of endometrial adenocarcinoma?
Associated medical conditions Data suggest that women who have had breast cancer have a 2- to 3-fold increased risk of subsequently developing endometrial cancer. Women who have hereditary nonpolyposis colon cancer (HNPCC) appear to have a markedly increased risk for developing endometrial cancer.
Can you live a long life after endometrial cancer?
They can’t tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful….5-year relative survival rates for endometrial cancer.
| SEER Stage | 5-year Relative Survival Rate |
|---|---|
| Distant | 17% |
| All SEER stages combined | 81% |
What is the life expectancy of someone with endometrial cancer?
When all types of endometrial cancer cases are combined the 5-year relative survival rate is about 83 percent. Most of these cases are diagnosed at an early stage and have a 5-year survival rate of 96 percent.
How does endometrial cancer metastasize?
Endometrial cancer very often metastasizes to the ovaries and fallopian tubes when the cancer is located in the upper part of the uterus, and the cervix when the cancer is in the lower part of the uterus. Usually, endometrial cancer first spreads into the myometrium and the serosa, and then to other pelvic organs.
What is the death rate for endometrial cancer?
Endometrial cancer is the fourth most common cancer in women, accounting for approximately 6,000 deaths per year in the United States. It is more common in women who are older, white, affluent, obese and of low parity.
What is the early stage of endometrial cancer?
Endometrial cancer begins in the layer of cells that form the lining (the endometrium) of the uterus (see Figures 1 and 3). Endometrial cancer is often detected at an early stage, because it frequently produces abnormal vaginal bleeding, which prompts women to see their health care providers.