What is Stromal cell-derived factor-1?
Stromal cell-derived factor-1 (SDF-1) is a secreted 89-amino acid protein that binds chemokine receptor type 4 (CXCR4), a seven-pass G-protein-coupled membrane receptor. Several cell types, including osteoblasts, fibroblasts, and endothelial cells, express SDF-1.
What is SDF disease?
Background: Peripheral artery disease is a potentially incapacitating disease for which pharmacological options are limited. Stromal cell-derived factor-1 (SDF-1) is a chemokine that attracts endothelial progenitor cells and promotes angiogenesis.
What produces CXCL12?
In the field of oncology, melanoma associated fibroblasts are stimulated by stimulation of the A2B adenosine receptor followed by stimulation of fibroblast growth factor and increased expression of CXCL12.
Is SDF-1 a chemokine?
SDF-1 was recently shown to be a chemokine which is chemotactic for different types of leukocytes and acts via the chemokine receptor CXCR4.
What are the stromal cells?
Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ.
What is the full form of SDF?
|SDF||System Data Format|
|SDF||Structured Data Format|
|SDF||Structured Directory Format|
|SDF||Service Data Function|
What is cellular stroma?
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary.
What does CXCL12 bind to?
CXCL12 fulfills its functions in homeostatic and pathological conditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a proper presentation to passing leukocytes.
What is the receptor for CXCL12?
CXCL12 acts through its receptors CXCR4 and CXCR7. CXCR4 stimulation leads to the activation of numerous signaling pathways depending on the cell types while CXCR7 has mainly been shown to be involved in scavenging CXCL12, although it can activate a MAP kinase pathway through β-arrestin in several systems.
What is sdf1 Alpha?
Overview. Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells.