What is the benefit of trimetazidine?
Trimetazidine helps to maintain the energy metabolism of heart muscle cells, protecting them from the effects of reduced oxygen supply. When you take this medication regularly on a long term basis, it can help treat angina by reducing the number of times you get angina.
How long can I take trimetazidine?
No significant adverse event or changes in clinical or biochemical parameters were detected. Conclusion: Treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced a functional improvement in patients with dilated cardiomyopathy.
Does trimetazidine lower blood pressure?
It was found that trimetazidine complies with several requirements for the effective drug administered to the patients with hypertension associated with ischemic heart disease as it: (a) reduces peripheral resistance and exerts favourable effect on the walls tonus of larger arteries; (b) lowers specifically post- …
Is trimetazidine bad for kidney?
Trimetazidine is contraindicated in patients with severe renal impairment. For patients with moderate renal impairment and the elderly, the dose should be reduced.
Is trimetazidine good for the heart?
Previous studies have shown that trimetazidine improves cardiac function by improving hemodynamics; however, the protective effect of trimetazidine on ischemic heart failure is not entirely due to its effects on the hemodynamic system.
What is the side effect of trimetazidine?
Trimetazidine has a significant side effects profile, with the most common adverse reactions being nausea, vomiting, fatigue, dizziness, and myalgia. The drug can induce or increase parkinsonian symptoms: extrapyramidal rigidity, bradykinesia, and tremor.
What is the best time to take trimetazidine?
The recommended dose of Trimetazidine 35 mg is one tablet to be taken two times a day during meals in the morning and evening. If you have kidney problems or if you are older than 75 years old, your doctor may adjust the recommended dose.
When should I take trimetazidine?
Is it safe to take trimetazidine?
Trimetazidine has been generally very well tolerated in clinical trials and usually only isolated cases of adverse events (ADRs—adverse drug reactions) were observed during trimetazidine treatment (mainly gastrointestinal disturbances, vomiting, nausea) [61].
How does trimetazidine hydrochloride tablets help the body?
Trimetazidine Hydrochloride Tablets improve the patients’ conditions by acting as a cytoprotective agent. It helps to store the energy levels in each cell. It maintains the metabolic balance of the body. It plays a crucial role in cardiovascular effectiveness. Studies show that it helps to normalize the metabolic disturbances in a patient.
Is it safe to take trimetazidine at 30 mL / minute?
Trimetazidine is not recommended for use in patients with severe renal impairment (CrCl less than 30 ml/minute) due to the increased risk of worsening of the patient’s condition.
What is the C Max of trimetazidine 35 mg?
In elderly patients, a 35 mg oral modified release tablet reaches a mean C max of 115 µg/L, with a T max of 2.0-5.0 hours, and a mean AUC 0-12 of 1104 h*µg/L. 3 In young, healthy patients, the same dose reaches a mean C max of 91.2 µg/L, with a T max of 2.0-6.0 hours, and an AUC 0-12h 720 h*µg/L. 3
What is the effect of trimetazidine on CRP?
Trimetazidine was shown to suppress the elevation of inflammatory markers such as CRP, TNF-α, and NO levels during coronary interventions, although in another study no significant difference between the levels of IL-8, TNF-α, C3 and C5, and highly sensitive CRP was observed.