Does ethambutol cause liver damage?

Ethambutol therapy has been associated with minor, transient and asymptomatic elevations in serum aminotransferase levels, and is a reported but rare cause of clinically apparent acute liver injury.

What are the signs and symptoms of hepatotoxicity?


  • Yellowing of the skin and whites of the eyes (jaundice)
  • Itching.
  • Abdominal pain in the upper right portion of the abdomen.
  • Fatigue.
  • Loss of appetite.
  • Nausea and vomiting.
  • Rash.
  • Fever.

What is the most common adverse effect of ethambutol?

SIDE EFFECTS: Headache, loss of appetite, upset stomach, or nausea/vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

How do I know if my medication is affecting my liver?

Symptoms and signs that are specific for liver disease include: yellowing of the skin (jaundice) due to the accumulation of bilirubin in the blood, itching associated with liver disease, and. easy bruising due to decreased production of blood clotting factors by the diseased liver.

Does TB medicines affect liver?

Anti-tuberculosis treatment is known to cause liver damage in 4 percent to 11 percent of patients mandating to stop the treatment till the liver enzymes come to normal. In ~0.1 percent cases this could prove fatal.

Which antibiotic has the lowest risk of liver toxicity?

Cephalosporins. Cephalosporins are only rarely implicated in hepatotoxic reactions.

What is ethambutol toxicity?

Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.

What is ethambutol side effects?

Common side effects may include:

  • itching or rash;
  • joint pain;
  • headache, dizziness; or.
  • nausea, vomiting, stomach pain, indigestion, loss of appetite.

Does TB affect liver?

Tuberculosis per se can affect liver in three forms. The most common form is the diffuse hepatic involvement, seen along with pulmonary or miliary tuberculosis. The second is granulomatous hepatitis and the third, much rarer form presents as focal/local tuberculoma or abscess.

How does TB medicine prevent liver damage?

A review of available literature suggests that reduction in lipid peroxide content in tissue and increase in superoxide dismutase, catalase, glutathione, glutathione-s-transferase and glutathione peroxidase activities should help to maintain liver cell integrity and control the increase in level of liver enzymes.

Are there any side effects from ethambutol toxicity?

( R) Painless. In most cases, the visual changes associated with ethambutol toxicity are completely painless. That said, some patients may experience painful throbbing or burning sensations in the eyes. ( R) Over 60% of patients exhibit bilateral, painless, symmetrical loss of visual acuity and/or abnormal color vision (red-green or blue-yellow).

What are the long term side effects of myambutol?

Side effects requiring immediate medical attention 1 Blurred vision, eye pain, red-green color blindness, or any loss of vision (more common with high doses) 2 fever 3 joint pain 4 numbness, tingling, burning pain, or weakness in hands or feet 5 skin rash

What are the side effects of ethambutol eye drops?

Ethambutol side effects. severe skin reaction–fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

What is ethambutol used to treat?

Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Ethambutol is used to treat tuberculosis (TB), and is usually given together with at least one other tuberculosis medicine.