What do you mean by Chromatolysis?

: the dissolution and breaking up of chromophil material (such as chromatin) of a cell and especially a nerve cell.

Why does Chromatolysis happen?

Chromatolysis is the dissolution of the Nissl bodies in the cell body of a neuron. It is an induced response of the cell usually triggered by axotomy, ischemia, toxicity to the cell, cell exhaustion, virus infections, and hibernation in lower vertebrates.

Is Chromatolysis reversible?

Chromatolysis is also reversible in CNS neurons.

Is Chromatolysis is seen in demyelination?

Chromatolytic motor neurons have been found in autopsies of patients with a wide range of acquired and inherited diseases, such as chronic inflammatory demyelinating polyneuropathy,316 acute motor axonal neuropathy/acute motor and sensory axonal neuropathy,161 Werdnig-Hoffmann disease,61 poliovirus,30 amyotrophic …

What is the function of Neurofibrils?

neurofibril Any of the fibres in the cytoplasm of a nerve axon. Neurofibrils include neurofilaments and neurotubules, microtubules that play a role in the transport of proteins and other substances within the cytoplasm.

What is Wallerian degeneration?

Wallerian degeneration is an active process of retrograde degeneration of the distal end of an axon that is a result of a nerve lesion. It occurs between 7 to 21 days after the lesion occurs. After the 21st day, acute nerve degeneration will show on the electromyograph.

What do you mean by Transneuronal degeneration?

Transneuronal degeneration is the death of neurons resulting from the disruption of input from or output to other nearby neurons.

What is Golgi stain used for?

Golgi’s method is a silver staining technique that is used to visualize nervous tissue under light microscopy. The method was discovered by Camillo Golgi, an Italian physician and scientist, who published the first picture made with the technique in 1873.

Which part of the neuron is most sensitive?

Between the axon itself and the soma is a portion of the neuron known as the axon hillock, the most sensitive portion of the nerve cell due to the high volume of sodium channels.

What happens when demyelination occurs?

A demyelinating disease is any condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, optic nerves and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems.

What are the function of myelin sheath?

Myelin is an insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty substances. This myelin sheath allows electrical impulses to transmit quickly and efficiently along the nerve cells.

What is the function of Axoplasm?

Axoplasm is integral to the overall function of neurons in propagating action potential through the axon. The amount of axoplasm in the axon is important to the cable like properties of the axon in cable theory.

Which is the best definition of chromatolysis?

Definition of chromatolysis. : the dissolution and breaking up of chromophil material (such as chromatin) of a cell and especially a nerve cell.

What is the medical term for Chromophil disintegration?

chro·ma·tol·y·sis. The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process. Synonym(s): chromolysis.

Which is an agent for the induction of chromatolysis?

Acrylamide intoxication has been shown to be an agent for the induction of chromatolysis. In one study groups of rats were injected with acrylamide for 3, 6, and 12 days and the A- and B-cell perikarya of their L5 dorsal root ganglion were examined.

What happens to the pink structures in chromatolysis?

In chromatolysis of motor neurons, these pink structures dissolve. When an axon is injured, the whole neuron reacts to provide increased metabolic activity that is necessary for regeneration of the axon. Part of this reaction includes structural alternations caused by the chromatolysis event.