What is pegloticase used for?
Pegloticase injection is used to treat ongoing gout (sudden, severe pain, redness, and swelling in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults who cannot take or did not respond to other medications.
What is the mechanism of action of pegloticase?
Mechanism of Action: a polyethylene glycol conjugate of uricase (urate oxidase) that converts uric acid into a more soluble compound that is easier to excrete. acts rapidly, producing a peak decline in uric acid levels within 24-72 hours.
How is KRYSTEXXA administered?
The KRYSTEXXA admixture should only be administered by intravenous infusion over no less than 120 minutes via gravity feed, syringe-type pump, or infusion pump. KRYSTEXXA is a clear, colorless, sterile 8 mg/mL solution of pegloticase in a 2 mL single- use vial, expressed as amounts of uricase protein.
How long do you take KRYSTEXXA?
Specialist: “KRYSTEXXA is taken every two weeks for about 6 months and can start dissolving years of gout buildup within 24 hours of the first treatment.”
Are bananas good for gout?
Bananas are low in purines and high in vitamin C, which make them a good food to eat if you have gout. Changing your diet to include more low-purine foods, like bananas, can lower the amount of uric acid in your blood and reduce your risk of recurrent gout attacks.
Which tablet is best for uric acid?
Your doctor may recommend one of these medicines that you can’t get over the counter:
- Allopurinol (Aloprim, Zyloprim)reduces uric acid production.
- Colchicine(Colcrys, Mitigare) reduces inflammation.
- Febuxostat(Uloric) reduces uric acid production.
- Indomethacin(Indocin, Tivorbex) is a stronger NSAID pain reliever.
Is pegloticase a Uricosuric?
When severe gout with tophi persists despite treatment with allopurinol, a xanthine oxidase inhibitor, the hypouricaemic drug of choice is probenecid, a uricosuric agent, in the absence of a better alternative. Pegloticase is a pegylated recombinant uricase.
Is Rasburicase the same as pegloticase?
Pegloticase is a recombinant porcine-like uricase. Similarly to rasburicase, it metabolises uric acid to allantoin. This reduces the risk of precipitates, since allantoin is five to ten times more soluble than uric acid.
What can dissolve uric acid crystals?
KRYSTEXXA has a different way of lowering uric acid levels, which is the key to stopping gout flares. In about 6 months, it can safely and effectively remove years of uric acid crystal buildup from your joints. KRYSTEXXA is also a safe option for uncontrolled gout even if you have kidney disease.