What are the symptoms of amiodarone toxicity?

The clinical presentation of amiodarone pulmonary toxicity is very nonspecific. Common symptoms are shortness of breath, dry cough, fever, respiratory distress, and fatigue; sometimes it can mimic acute respiratory distress syndrome.

Why does amiodarone cause pulmonary toxicity?

Amiodarone may induce the production of toxic O2 radicals, which can directly damage cells (9). It also appears to promote the accumulation of phospholipids in tissues (9). Typically, the lungs of patients with APT show a diffuse interstitial pneumonitis on microscopic inspection (Figure 1).

What are the symptoms of pulmonary toxicity?

What are the symptoms of lung toxicity?

  • Breathlessness during exercise.
  • Fatigue.
  • Dry cough.
  • Shortness of breath.
  • Discomfort or worsening symptoms when lying on your back.

How long do side effects last after stopping amiodarone?

This medication can make your skin more sensitive than usual to sunlight and sunlamps, which could cause a serious burn. This effect may continue for weeks or months after you stop taking amiodarone. If you will be outside for long periods of time, wear protective clothing and use a sunscreen.

Which of the following is an adverse effect of amiodarone?

Commonly reported side effects of amiodarone include: hypersensitivity pneumonitis, interstitial pneumonitis, pulmonary toxicity, pulmonary alveolitis, hypotension, corneal deposits, ataxia, blurred vision, decreased visual acuity, dermatological reaction, gastrointestinal signs and symptoms, peripheral neuropathy.

What is the most common drug induced respiratory problems?

Interstitial pneumonitis (ie, inflammation of the lung interstitium, such as the alveolar septa) is the most common manifestation of drug-induced lung disease. A wide array of drugs can cause interstitial pneumonitis.

Can amiodarone cause lung damage?

Amiodarone may cause lung damage that can be serious or life-threatening. Tell your doctor if you have or have ever had any type of lung disease or if you have ever developed lung damage or breathing problems while taking amiodarone.

Will taking amiodarone cause toxicity?

Amiodarone can cause pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 17% in some series of patients. Pulmonary toxicity has been fatal about 10% of the time.

Does amiodarone cause pulmonary hypertension?

Pulmonary hypertension is found among people who take Amiodarone hydrochloride, especially for people who are female, 60+ old also take medication Movicol, and have Rheumatoid arthritis.

Can amiodarone cause pulmonary embolism?

Pulmonary embolism is found among people who take Amiodarone hydrochloride , especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Furosemide , and have Pneumonia.