What is BFM protocol?
A modified version of the standard Berlin-Frankfurt-Munich (BFM) protocol for pediatric ALL was developed to achieve balance between toxicity and favorable response rates. Modification included a dose reduction of asparaginase and methotrexate during the consolidation and reinduction phase.
What is BFM chemotherapy?
During Induction, you will receive augmented Berlin-Frankfurt-Munster chemotherapy, which is made up of a combination of Cerubidine®, Daunorubicin Hydrochloride (daunorubicin), Oncovin® (vincristine), prednisone, dexamethasone, Oncaspar® (PEG Asparaginase), and MTX amethopterin (methotrexate).
How long is the treatment for acute lymphoblastic leukemia?
The total treatment usually takes about 2 years, with the maintenance phase taking up most of this time. Treatment may be more or less intense, depending on the subtype of ALL and other prognostic factors.
What is regimen in oncology?
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy.
What is aBFM regimen?
The aBFM regimen includes a second interim maintenance phase and intensification phase, as well as additional vincristine and L-asparaginase during the consolidation and reconsolidation phases.
How long does L asparaginase take to work?
Results: Overall response rate for dogs treated with this protocol was 87% (27/31), with 52% (16/31) of dogs achieving a complete response. Median time to response was 21 days. Median time to progression was 63 days (111 days for dogs achieving a complete response and 42 days for dogs achieving a partial response).
What are 2 primary uses for asparaginase?
Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL). It is given by injection into a vein, muscle, or under the skin….Asparaginase.
What are the strongest chemotherapy?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can’t take it indefinitely.
Which is the standard arm for ALL BFM 2000?
The ALL- BFM 2000 standard arm has been used as the treatment regimen in this protocol, since it is common to both ALL-BFM95 and ALL- BFM 2000 regimens. If minimal residual disease (MRD) testing is available, then the incorporation of these results appears justified on the published data, at least for the pre-B ALL group. r
What are the results of aieop-BFM all 2000?
After adjusting for waiting time to transplantation, their 5-year EFS was 51.7% (6.6) compared with a 5-year EFS of 44.6% (5.8) in patients with the same features and treated given chemotherapy only (p=0.72). These data show that AIEOP-BFM ALL 2000 HR therapy is very effective for patients defined at HR for PPR.
When does induction 1A begin for BFM 2000?
Induction 1A has an initial 7 days of prephase with prednisolone and intrathecal methotrexate which is included in this protocol. Protocol II begins 2 weeks after the end of Protocol M for standard risk and medium risk patients. i.e. on day 70 after the start of Protocol M.
Which is all-bfm95 regimen for precursor B all?
The ALL-BFM95 regimen was used as the standard arm of ALL-BFM 2000 with the incorporation of the minimal residual disease testing in patients with precursor B ALL.